Synthesized and hypothesized schiff base ligand and its metal(II) complexes DNA binding mode
نویسندگان
چکیده
ABSTRACT. Metal complexes play an important role in agriculture, pharmacology, medicine, and industrial chemistry. Schiff base metal compounds are the fusion products of propene aldehydes, require a surrounded by ion or cluster molecules to form. Co(II), Ni(II), Cu(II), Zn(II) have also been created. Elemental analysis is used analyses structure related produced ligand. According deoxyribose nucleic acid (DNA) binding tests, metal(II) attach DNA intercalative form with weak covalent connections. The predicted mode supports increase complexes' activity presence newly generated cleavage activities were recorded using gel-electrophoresis absence complexes. findings experiment show that all chelates can successfully cut DNA.
 
 KEY WORDS: ligand, DNA, Metal(II) complex, Hetero-ligand cobalt(II), Aldehydes
 Bull. Chem. Soc. Ethiop. 2023, 37(5), 1133-1139. DOI: https://dx.doi.org/10.4314/bcse.v37i5.6
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ژورنال
عنوان ژورنال: Bulletin of The Chemical Society of Ethiopia
سال: 2023
ISSN: ['1011-3924', '1726-801X']
DOI: https://doi.org/10.4314/bcse.v37i5.6